Alternative cancer treatment, alternative breast cancer
treatment, alternative prostate cancer treatment
ADENOCARCINOM CANCER
/ AIDS LYMPHOMA CANCER / BRAIN CANCER TUMOR / BREAST
CANCER
SINUS SARCOMA CANCER /
INFLAMMATORY
BREAST CANCER (IBC) TUMOR / PROSTATE CANCER TUMOR / TONSIL CANCER TUMOR
NECK CANCER TUMOR I / NECK CANCER TUMOR II / BREAST
CANCER, HEAD and NECK TUMOR, DEEP TUMORS
Neck TumorAlternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment
Neck cancer treatmentAlternative cancer treatment, alternative breast cancer
treatment, alternative prostate cancer treatment
An FDA approved alternative cancer treatment
One patient's result. These pictures were taken before and after the Hyperthermia
treatment, combined with low radiation dose, on a neck cancer patient. Alternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment
Before treatment, 02/28/07
Before treatment, 02/28/07
Before treatment,
02/28/07
After treatment, 03/08/07
After treatment, 03/08/07
After
five weeks of reatment, 04/09/07
After five weeks of reatment,
04/09/07
After seven weeks of reatment, 04/17/07
After
seven weeks of reatment, 04/17/07
After 9 weeks of treatment, 04/30/07
After 9 weeks of treatment, 04/30/07
After 10 weeks of
treatment, 05/07/07
After 10 weeks of treatment,
05/07/07 Before
treatment, 02/28/07
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Scientific paper presented by Dr. James I. Bicher, in the 2002 International Clinical
Hyperthermia Society Meeting, Florida, USA.
PROTRACTED THERMORADIOTHERAPY
TREATING TO EFFECT WITH OBJECTIVE END POINTS.
James I. Bicher, M. D.
Valley Cancer Institute, Los Angeles, CA, U.S.A
Hyperthermia has been proven to increase the response of malignant
tumors to radiation therapy in both experimental animal tumors and the clinical treatment
of human cancer. Based on our multi-year experience, first in re-treatment of previously
radiated fields that necessitated the use of low dose radiation fractions as adjunct to
the heat treatments, and then progressively applying the encouraging results obtained to
areas treated "de novo" and eventually to situations allowing a potentially
curative intent, treatment protocols have been devised and tested that yield positive
preliminary data showing superior tumor response rates and less side effects when compared
with historical controls at our Institute.
The hyperthermia part of the protocol extends the number of heat
treatments to correspond to the number of radiation-fractions, as each hyperthermia
treatment proceeds or follows each radiation treatment in close time proximity. The number
of hyperthermia treatments therefore varies from 25-50 per course for each treated field.
Outcomes confirm that more Hyperthermia fractions improve both tumor response and
survival.
The radiation protocol consists of progressively decreasing daily doses
of radiation therapy combined with the daily hyperthermia treatments. Typically the
treatment is started at a daily dose of 180cGy gradually reduced to 100cGy protracting a
typical radiation therapy treatment course from 5000cGy in five weeks to 5000cGy given in
over eight weeks; or 7000cGy in seven weeks to 7000cGy in 14 weeks. According to the ELLIS
TDF formula, this results in a 15% or 25% reduction of the effective radiation dose. The
total dose is of course adapted to the clinical situation. To this effect, the use of
objective end result parameters is introduced, including MR Spectroscopy, PET Scanning and
Tumor Marker levels. Increased radiation doses improve tumor response, but not survival,
when enough Hyperthermia is given. Increased Hyperthermia doses, increase both response
and survival.
CONCLUSIONS
Protracted Hyperfractionation
- Decreases the radiation dose by 15% and 25%.
- Decreases the side effects of XRT (no diarrhea, fistula or pneumonitis in PH cases).
- Allows for more combined XRT-Hyperthermia treatments.
- Increases the effectiveness of the combined treatment in superficial and deep tumors.
- More Hyperthermia increases tumor response and survival.
- More Radiation improves tumor response but not survival when enough Hyperthermia is
given.
Question: What is the lowest radiation dose needed to potentiate
Hyperthermia?
